Glave attended Ohio University.
Glave has appeared in numerous television shows, including recurring roles as Deputy Bud Skeeter on Picket Fences, Dr. Dale Edson in ER, Colonel Paul Emerson in Stargate SG-1, and Lt. Colonel Evan Connors in Army Wives.
He has also appeared in Cheers, NYPD Blue, X-Files, and CSI, Charmed, Will & Grace, among others. He played Glenn Gulia in 1998's The Wedding Singer, alongside Adam Sandler and Drew Barrymore. He also played the brother to Mark Wahlberg in the movie Rock Star, in 2000. He played Bennington Cotwell in the 1994 film Baby's Day Out. In 2011, he played the antagonist Dr. Olson in Disney Channel's The Suite Life Movie. He also played Dave in My Name Is Earl.
He appeared in the second episode ABC drama series Revenge, as wealthy Wall Street hedge fund manager Bill Harmon, in September, 2011.